zum Inhalt springen

Publikationen

Mitglieder der Arbeitsgruppe haben zum Review-Prozess folgender Zeitschriften beigetragen:
PNAS, Journal of Neuroscience, Journal of Cell Science, Pain, PLOS ONE, Journal of Neurochemistry, Brain Research, Neuroscience, European Journal of Neuroscience, FEBS Journal, Journal of Biochemistry, Journal of Molecular Medicine, Journal of Neuroendocrinology, Journal of Neuroscience Methods, Experimental Gerontology, Neurochemical Research, Neuroscience Research, Pharmaceutics, Postgraduate Medical Journal.

Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling
Pinheiro-Junior EL, Alirahimi E, Peigneur S, Isensee J, Schiffmann S, Erkoc P, Fürst R, Vilcinskas A, Sennoner T, Koludarov I, Hempel BF, Tytgat J, Hucho T, von Reumont BM.
BMC Biol. 2024 Jul
doi: 10.1186/s12915-024-01955-5.
PMID: 39075558

Non-obese lipedema patients show a distinctly altered quantitative sensory testing profile with high diagnostic potential
Rebecca Dinnendahl, Dominik Tschimmel, Vanessa Löw, Manuel Cornely, Tim Hucho
Pain Rep. 2024 Apr

doi: 10.1097/PR9.0000000000001155. eCollection 2024 Jun.
PMID: 38617100

[Lipedema pain-the neglected symptom].
Hucho T
Dermatologie (Heidelb), 2023 August

doi: 10.1007/s00105-023-05189-4. Epub 2023 Jul 12. PMID: 37438647

Emergence of nociceptive functionality and opioid signaling in human iPSC-derived sensory neurons.
Röderer P, Belu A, Heidrich L, Siobal M, Isensee J, Prolingheuer J, Janocha E, Valdor M, Hagendorf S, Bahrenberg G, Opitz T, Segschneider M, Haupt S, Nitzsche A, Brüstle O, Hucho T.
Pain. 2023 August
doi: 10.1097/j.pain.0000000000002860.
Online ahead of print.PMID: 36727909

Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake.
Klein I, Isensee J, Wiesen MHJ, Imhof T, Wassermann MK, Müller C, Hucho T, Koch M, Lehmann HC.
Cells,  2023 April
doi: 10.3390/cells12091249. PMID: 37174648

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse    
Overhoff M, Tellkamp F, Hess S, Tolve M, Tutas J, Faerfers M, Ickert L, Mohammadi M, De Bruyckere E, Kallergi E, Delle Vedove A, Nikoletopoulou V, Wirth B, Isensee J, Hucho T, Puchkov D, Isbrandt D, Krueger M, Kloppenburg P, Kononenko NL.
EMBO J. 2022 October
doi: 10.15252/embj.2022110963;       PMID: 36217825

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer
Ratz L, Brambillasca C, Bartke L, Huetzen MA, Goergens J, Leidecker O, Jachimowicz RD, van de Ven M, Proost N, Siteur B, de Korte-Grimmerink R, Bouwman P, Pulver EM, de Bruijn R, Isensee J, Hucho T, Pandey G, van Lohuizen M, Mallmann P, Reinhardt HC, Jonkers J, Puppe J.
Breast Cancer Res, 2022 June
doi: 10.1186/s13058-022-01534-y;     PMID: 35715861

Modern venomics-Current insights, novel methods, and future perspectives in biologiical and applied animal venom research
von Reumont BM, Anderluh G, Antunes A, Ayvazyan N, Beis D, Caliskan F, Crnković A, Damm M, Dutertre S, Ellgaard L, Gajski G, German H, Halassy B, Hempel BF, Hucho T, Igci N, Ikonomopoulou MP, Karbat I, Klapa MI, Koludarov I, Kool J, Lüddecke T, Ben Mansour R, Vittoria Modica M, Moran Y, Nalbantsoy A, Ibáñez MEP, Panagiotopoulos A, Reuveny E, Céspedes JS, Sombke A, Surm JM, Undheim EAB, Verdes A, Zancolli G.
Gigascience, 2022 May
DOI: 10.1093/gigascience/giac048;         PMID: 35640874                    

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2 + DRG sensory neurons 
Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM.
Nat Neurosci. 2022 Feb;25(2):168-179. doi: 10.1038/s41593-021-00973-8. Epub 2021 Dec 20. PMID: 34931070

Biallelic variants in YRDC cause a developmental disorder with progeroid features
Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, Werner G, Altmüller J, Thiele H, Nürnberg P, Isensee J, Li Y, Müller C, Leube B, Reinhardt HC, Hucho T, Salinas G, Helm M, Jachimowicz RD, Wieczorek D, Kohl T, Lehnart SE, Yigit G, Wollnik B.
Hum Genet. 2021 Dec;140(12):1679-1693. doi: 10.1007/s00439-021-02347-3. Epub 2021 Sep 20. PMID: 34545459

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents 
Cai S, Moutal A, Yu J, Chew LA, Isensee J, Chawla R, Gomez K, Luo S, Zhou Y, Chefdeville A, Madura C, Perez-Miller S, Bellampalli SS, Dorame A, Scott DD, François-Moutal L, Shan Z, Woodward T, Gokhale V, Hohmann AG, Vanderah TW, Patek M, Khanna M, Hucho T, Khanna R.
Sci Transl Med. 2021 Nov 10;13(619):eabh1314. doi: 10.1126/scitranslmed.abh1314. Epub 2021 Nov 10. PMID: 34757807

Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation 
Jörg IsenseeMarianne van Cann  Patrick Despang Dioneia Araldi Katharina MoellerJonas PetersenAchim SchmidtkoJan Matthes Jon D LevineTim Hucho 
J Cell Biol. 2021 Oct 4;220(10):e202002083. doi: 10.1083/jcb.202002083. Epub 2021 Aug 25.
PMID: 34431981; DOI: 10.1083/jcb.202002083

Pericentromeric Satellite III transcripts induce etoposide resistance. 
Kanne J, Hussong M, Isensee J, Muñoz-López Á, Wolffgramm J, Heß F, Grimm C, Bessonov S, Meder L, Wang J, Reinhardt HC, Odenthal M, Hucho T, Büttner R, Summerer D, Schweiger MR.
Cell Death Dis. 2021 May 24;12(6):530. doi: 10.1038/s41419-021-03810-9. PMID: 34031359

Prostate-Specific Membrane Antigen Uptake in a Peripheral Nerve and Respective Ganglia on 68Ga-Prostate-Specific Membrane Antigen-HBED-CC PET/CT.
Mettler J, Drzezga A, Dietlein M, Hucho T, Kobe C.
Clin Nucl Med. 2021 Jan;46(1):69-70. doi: 10.1097/RLU.0000000000003401. PMID: 33208621

Positron-Emission-Tomography Imaging of Long-Term Expression of the 18kDa
Schroeder DC, Popp E, Rohleder C, Vus S, Bethencourt DP, Finke SR, Zlatopolskiy BD, Zischler J, Drzezga A, Herff H, Annecke T, Hucho T, Neumaier B, Böttiger BW, Endepols H.
Shock. 2020 May 18. doi: 10.1097/SHK.0000000000001546. Online ahead of print. PMID: 32433203

Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA
Garza Carbajal A, Ebersberger A, Thiel A, Ferrari L, Acuna J, Brosig S, Isensee J, Moeller K, Siobal M, Rose-John S, Levine J, Schaible HG, Hucho T.
J Neurochem. 2020 Sep 3. doi: 10.1111/jnc.15172. Online ahead of print. PMID: 32885411

Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis
Loeser J, Layer B, Plata C, Perrar KM, Hucho T, Kulbida R.
J Integr Med. 2020 Sep;18(5):425-433. doi: 10.1016/j.joim.2020.07.003. Epub 2020 Jul 18 PMID: 32732108

Scorpion toxin MeuNaTxα‐1 sensitizes primary nociceptors by selective modulation of voltage‐gated sodium channels
van Cann M, Kuzmenkov A, Isensee J, Andreev-Andrievskiy A, Peigneur S, Khusainov G, Berkut A, Tytgat J, Vassilevski A, Hucho T.
FEBS J. 2020 Oct 13. doi: 10.1111/febs.15593. Online ahead of print. PMID: 33051988

Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α2δ-1 with thrombospondin-4
El-Awaad E, Pryymachuk G, Fried C, Matthes, Isensee J, Hucho T, Neiss WF, Paulsson M, Herzig S, Zaucke F, Pietsch M.
Scientific Reports. 2019 Nov,; 9:16272 PMID: 31700036

Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells.
Erber J, Steiner JD, Isensee J, Lobbes LA, Toschka A, Beleggia F, Schmitt A, Kaiser RWJ, Siedek F, Persigehl T, Hucho T, Reinhardt HC.
Cancer Res. 2019 Oct 1;79(19):4855-4868. doi: 10.1158/0008-5472.CAN-18-3959. Epub 2019 Aug 12. PMID: 31405847

High-Content Imaging of Immunofluorescently Labeled TRPV1-Positive Sensory Neurons.
Isensee J, Hucho T.
Methods Mol Biol. 2019;1987:111-124. doi: 10.1007/978-1-4939-9446-5_8. PMID: 31028677

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.
Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PMID: 30612738

The beta-adrenergic receptor agonist, terbutaline, reduces UVB-induced mechanical sensitization in humans.
Loeser J, Blunk JA, Ruschulte H, Knitsch J, Karst M, Hucho T.
Eur J Pain. 2019 Jan;23(1):72-80. doi: 10.1002/ejp.1286. Epub 2018 Aug 6. PMID: 29984439

The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression.
Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B, Reinhardt HC.
Cell Rep. 2018 Oct 23;25(4):1027-1039.e6. doi: 10.1016/j.celrep.2018.09.079. PMID: 30355482

Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest.
Schroeder DC, Maul AC, Mahabir E, Koxholt I, Yan X, Padosch SA, Herff H, Bultmann-Mellin I, Sterner-Kock A, Annecke T, Hucho T, Böttiger BW, Guschlbauer M.
BMC Anesthesiol. 2018 Jun 5;18(1):61. doi: 10.1186/s12871-018-0530-8. PMID: 29866034
Full text

A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability
Loos C, Moeller K, Fröhlich F, Hucho T, Hasenauer J
Cell Syst. 2018 May 23;6(5):593-603.e13. doi: 10.1016/j.cels.2018.04.008. Epub 2018 May 2. PMID:29730254

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination
Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T
J Cell Biol. 2018 Apr 3. pii: jcb.201708053. doi: 10.1083/jcb.201708053. [Epub ahead of print]
Editorial:
Protein kinase A activation: Something new under the sun?
Smith FD, Scott JD.
J Cell Biol. 2018 May 17. pii: jcb.201805011. doi: 10.1083/jcb.201805011. [Epub ahead of print]

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.
Lechner A, Schlößer H, Rothschild SI, Thelen M, Reuter S, Zentis P, Shimabukuro-Vornhagen A, Theurich S, Wennhold K, Garcia-Marquez M, Tharun L, Quaas A, Schauss A, Isensee J, Hucho T, Huebbers C, von Bergwelt-Baildon M, Beutner D.
Oncotarget. 2017 Jul 4;8(27):44418-44433. doi: 10.18632/oncotarget.17901. PMID:28574843


Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.
Isensee J, Schild C, Schwede F, Hucho T
J Cell Sci. 2017 May 17. pii: jcs.197327. doi: 10.1242/jcs.197327. PMID: 28515230 DOI: 10.1242/jcs. 197327

HCS-Mikroskopie – ein Schlüssel zu intrazellulären Schmerzmechanismen
Isensee J, Hucho T
Biospektrum (2017) 23: 277. doi: 10.1007/s12268-017-0796-2

Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.
Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg FW, Schwede F, Stein C, Jordt SE, Brackmann M, Spahn V.
Eur J Pain. 2017 Feb 9. doi: 10.1002/ejp.1008. [Epub ahead of print] PMID: 28182310

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice
Isensee J, Krahé L, Moeller K, Pereira V, Sexton JE, Sun X, Emery E, Wood JN, Hucho T.
Nucleic Acids Res. 2017 Jan 9;45(1):382-394. doi: 10.1093/nar/gkw729. Epub 2016 Aug 17. PMID: 27536004

The bromodomain protein BRD4 regulates splicing during heat shock.
Hussong M, Kaehler C, Kerick M, Grimm C, Franz A, Timmermann B, Welzel F, Isensee J, Hucho T, Krobitsch S, Schweiger MR.
Nucleic Acids Res. 2017 Jan 9;45(1):382-394. doi: 10.1093/nar/gkw729. Epub 2016 Aug 17. PMID: 27536004 PMID: 27536004

Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit.770
Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss AW, Hucho T.
PLoS One. 2014 Dec 31;9(12):e115731. doi: 10.1371/journal.pone.0115731. eCollection 2014. PMID: 25551770 [PubMed - in process]

[1 + 1 = 0 : Reprogramming of nociceptors.]
Hucho T.
Schmerz. 2014 Aug 10. [Epub ahead of print] German. No abstract available. PMID:25106825  [PubMed - as supplied by publisher]

ODE Constrained Mixture Modelling: A Method for Unraveling Subpopulation Structures and Dynamics.
Hasenauer J, Hasenauer C, Hucho T, Theis FJ.
PLoS Comput Biol. 2014 Jul 3;10(7):e1003686. doi: 10.1371/journal.pcbi.1003686. eCollection 2014 Jul. PMID: 24992156[PubMed - in process  Free PMC Article

5-Fluorouracil affects assembly of stress granules based on RNA incorporation
Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch S.
Nucleic Acids Res. 2014 Apr 11. [Epub ahead of print] PMID: 24728989 [PubMed - as supplied by publisher]

Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, Allgöwer F, Herberg FW, Hucho T.
J Cell Sci. 2014 Jan 1;127(Pt 1):216-29. doi: 10.1242/jcs.136580. Epub 2013 Nov 4. PMID:24190886 [PubMed - as supplied by publisher]

Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia.
Andres C, Hasenauer J, Ahn HS, Joseph EK, Isensee J, Theis FJ, Allgöwer F, Levine JD, Dib-Hajj SD, Waxman SG, Hucho T.
Pain. 2013 Oct;154(10):2216-26. doi: 10.1016/j.pain.2013.07.005. Epub 2013 Jul 16. PMID:23867734 [PubMed - in process]

Ataxin-2-like is a regulator of stress granules and processing bodies.
Kaehler C, Isensee J, Nonhoff U, Terrey M, Hucho T, Lehrach H, Krobitsch S.
PLoS One. 2012;7(11):e50134. doi: 10.1371/journal.pone.0050134. Epub 2012 Nov 27. PMID:23209657 [PubMed - indexed for MEDLINE] Free PMC Article

Ca++/CaMKII switches nociceptor-sensitizing stimuli into desensitizing stimuli.
Hucho T, Suckow V, Joseph EK, Kuhn J, Schmoranzer J, Dina OA, Chen X, Karst M, Bernateck M, Levine JD, Ropers HH.
J Neurochem. 2012 Nov;123(4):589-601. doi: 10.1111/j.1471-4159.2012.07920.x. Epub 2012 Sep 28. PMID: 22891703 [PubMed - indexed for MEDLINE]

Threshold-free population analysis identifies larger DRG neurons to respond stronger to NGF stimulation.
Andres C, Hasenauer J, Allgower F, Hucho T.
PLoS One. 2012;7(3):e34257. doi: 10.1371/journal.pone.0034257. Epub 2012 Mar 27. PMID:22479579 [PubMed - indexed for MEDLINE] Free PMC Article

ST3GAL3 mutations impair the development of higher cognitive functions.
Hu H, Eggers K, Chen W, Garshasbi M, Motazacker MM, Wrogemann K, Kahrizi K, Tzschach A, Hosseini M, Bahman I, Hucho T, Mühlenhoff M, Gerardy-Schahn R, Najmabadi H, Ropers HH, Kuss AW.
Am J Hum Genet. 2011 Sep 9;89(3):407-14. doi: 10.1016/j.ajhg.2011.08.008. PMID:21907012 [PubMed - indexed for MEDLINE] Free PMC Article

Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway.
Goswami C, Kuhn J, Dina OA, Fernández-Ballester G, Levine JD, Ferrer-Montiel A, Hucho T.
J Neurochem. 2011 Jun;117(6):995-1008. doi: 10.1111/j.1471-4159.2011.07270.x. Epub 2011 May 13. PMID:21480900 [PubMed - indexed for MEDLINE]

Impaired left-ventricular cardiac function in male GPR30-deficient mice.
Delbeck M, Golz S, Vonk R, Janssen W, Hucho T, Isensee J, Schäfer S, Otto C.
Mol Med Rep. 2011 Jan-Feb;4(1):37-40. doi: 10.3892/mmr.2010.402. Epub 2010 Nov 30. PMID:21461560 [PubMed - indexed for MEDLINE] 

Quantitative automated microscopy (QuAM) elucidates growth factor specific signalling in pain sensitization.
Andres C, Meyer S, Dina OA, Levine JD, Hucho T.
Mol Pain. 2010 Dec 27;6:98. doi: 10.1186/1744-8069-6-98. PMID: 21187008 [PubMed - indexed for MEDLINE] Free PMC Article

Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.
Goswami C, Kuhn J, Heppenstall PA, Hucho T.
PLoS One. 2010 Jul 19;5(7):e11654. doi: 10.1371/journal.pone.0011654. PMID:20657843 [PubMed - indexed for MEDLINE]  Free PMC Article

TRPV1 acts as a synaptic protein and regulates vesicle recycling.
Goswami C, Rademacher N, Smalla KH, Kalscheuer V, Ropers HH, Gundelfinger ED, Hucho T.
J Cell Sci. 2010 Jun 15;123(Pt 12):2045-57. doi: 10.1242/jcs.065144. Epub 2010 May 18. PMID:20483957 [PubMed - indexed for MEDLINE] Free Article

Novel aspects of the submembraneous microtubule cytoskeleton.
Goswami C, Hucho T.
FEBS J. 2008 Oct;275(19):4653. doi: 10.1111/j.1742-4658.2008.06613.x. Epub 2008 Aug 27. No abstract available. PMID:18754777 [PubMed - indexed for MEDLINE]

Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton.
Goswami C, Hucho T.
FEBS J. 2008 Oct;275(19):4684-99. doi: 10.1111/j.1742-4658.2008.06617.x. Epub 2008 Aug 27. Review. PMID:18754773 [PubMed - indexed for MEDLINE]

GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat.
Kuhn J, Dina OA, Goswami C, Suckow V, Levine JD, Hucho T.
Eur J Neurosci. 2008 Apr;27(7):1700-9. doi: 10.1111/j.1460-9568.2008.06131.x. Epub 2008 Mar 26. PMID:18371086 [PubMed - indexed for MEDLINE]

A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.
Motazacker MM, Rost BR, Hucho T, Garshasbi M, Kahrizi K, Ullmann R, Abedini SS, Nieh SE, Amini SH, Goswami C, Tzschach A, Jensen LR, Schmitz D, Ropers HH, Najmabadi H, Kuss AW.
Am J Hum Genet. 2007 Oct;81(4):792-8. Epub 2007 Aug 31. PMID:17847003 [PubMed - indexed for MEDLINE] Free PMC Article

TRPV1 expression-dependent initiation and regulation of filopodia.
Goswami C, Hucho T.
J Neurochem. 2007 Nov;103(4):1319-33. Epub 2007 Aug 20. PMID:17714453 [PubMed - indexed for MEDLINE]

Signaling pathways in sensitization: toward a nociceptor cell biology.
Hucho T, Levine JD.
Neuron. 2007 Aug 2;55(3):365-76. Review. PMID:17678851 [PubMed - indexed for MEDLINE]

Identification and characterisation of novel tubulin-binding motifs located within the C-terminus of TRPV1.
Goswami C, Hucho TB, Hucho F.
J Neurochem. 2007 Apr;101(1):250-62. Epub 2007 Feb 9. PMID: 17298389 [PubMed - indexed for MEDLINE]

Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons.
Hucho TB, Dina OA, Kuhn J, Levine JD.
Eur J Neurosci. 2006 Jul;24(2):527-34. Epub 2006 Jul 12. PMID:16836642 [PubMed - indexed for MEDLINE]

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.
Hucho TB, Dina OA, Levine JD.
J Neurosci. 2005 Jun 29;25(26):6119-26. PMID:15987941 [PubMed - indexed for MEDLINE] Free Article

Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.
Dina OA, Hucho T, Yeh J, Malik-Hall M, Reichling DB, Levine JD.
Pain. 2005 May;115(1-2):191-203. PMID:15836982 [PubMed - indexed for MEDLINE] Related citations Select item 1457245522.

Regulation, cellular localization, and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons. Gschwendtner A, Liu Z, Hucho T, Bohatschek M, Kalla R, Dechant G, Raivich G.
Mol Cell Neurosci. 2003 Oct;24(2):307-22. PMID:14572455 [PubMed - indexed for MEDLINE] Related citations